SOCS1-dependent control of the oncogenic functions of the CDK inhibitor p21CIP1/WAF1

  • Discovering new ways to inhibit liver cancer:
    Liver cancer is one of the leading causes of cancer death. Development of effective treatments for liver cancer requires a better understanding of the underlying molecular mechanisms. Many genes and their protein products control the growth of liver cells. Research in our laboratory is focused on a molecule called SOCS1. Studies on human patients and animal models suggest that SOCS1 plays a key role in preventing liver tumor. However, the underlying mechanisms are not known. By elucidating how SOCS1 regulates the growth of liver cells, we hope to gain insight into events that transform a normal liver cell into a cancer cell. This knowledge could serve as a basis for developing new therapeutic strategies to treat liver cancer patients.

Research focus :

 

Team

 
Subburaj Ilangumaran
Gerardo Ferbeyre
 

Research center:

Université de Sherbrooke
Sherbrooke, Quebec

 

Amount of funding

   
2012-2013: $60,000
2013-2014: $60,000
  $120,000
   

 

Research program

 
Operating Grant
The operating grant is the principal means by which the Cancer Research Society supports research activities by a scientist or a team of scientists.